Sumo ythdf2

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August undefined, 2024

WebReference Cited Chemicals Cited Genes Cited Diseases Cited Phenotypes Cited Anatomical Terms; 1. WebYTHDF2 deficiency in TAMs suppressed tumor growth by reprogramming TAMs toward an antitumoral phenotype and increasing their antigen cross-presentation ability, which in …

SUMOylation of YTHDF2 promotes mRNA degradation …

Web10 Apr 2024 · YTHDF2 preferentially bound to m 6 A-methylated CCND1 mRNA and diminished its expression, partially arresting MCE and inhibiting adipogenesis . Secondly, m 6 A reader YTHDF2 can modulate JAK/STAT signaling pathway. Wu et al. observed that there was a negative relationship between the expression of JAK2 mRNA and m 6 A level … WebYTHDF2-001: 2925: 579aa: ENSP00000362918.3 . Gene/transcipt that contains an open reading frame (ORF). Protein coding. CCDS41296: Q9Y5A9 S4R3J8: NM_016258.2: The GENCODE set is the gene set for human and mouse. GENCODE Basic is a subset of representative transcripts (splice variants). GENCODE basic, ENST00000542507.1: … smith and wesson 357 7 shot 6 inch barrel

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Web10 Apr 2024 · It has also been proposed that METTL14 methylates mRNAs that are targets of YTHDF2, thereby bringing in this reader [55] . Its binding may then transfer the mRNA to cellular locations where it can be degraded. ... M., Hansen, K., Puustinen, P., Gromova, I., et al. (2024) Release of Transcriptional Repression via ErbB2-Induced, SUMO-Directed ... Web18 Mar 2024 · YTHDF2 was modified by SUMO1 with a size of Mr ∼95–100 kDa (the expected normal size of YTHDF2 is 70 kDa), which is YTHDF2 covalently conjugated with … Web11 Nov 2024 · The expression of WTAP was higher in cluster 1 and YTHDF2 was lower, but it was opposite in cluster 2. Cluster 1 had stronger immune infiltration, more ICIs target expression, more TMB. In addition, WGCNA identified 22 genes associated with WTAP/ YTHDF2 expression and immune score, including TIM3 (HAVCR2) and CD86. smith and wesson 357 blued

YTHDF2 mediates the mRNA degradation of the tumor

(PDF) SUMOylation of YTHDF2 promotes mRNA degradation

Web12 Feb 2024 · Our works uncover a new regulatory mechanism for YTHDF2 recognition of m6A-RNAs and highlight the importance of YTHDF2 SUMOylation in post-transcriptional … WebYTHDF2 was transferred into SW1990 and PaTu8988 cells, and then YTHDF2 overexpression was examined at mRNA by real-time PCR (Fig. S1A). Unexpectedly, no signiﬁcant changes in the level of protein were observed in YTHDF2 overexpres-sion group (Fig. S1B). Subsequently, we identiﬁed plasmids Vector and Flag-YTHDF2 in H293T cell, … smith and wesson 357 ctg highway patrolmanWeb29 Aug 2024 · The mRNA N 6-methyladenosine (m 6 A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m 6 A mRNA reader YTHDF2, which recognizes m 6 A-modified transcripts to promote m 6 A-mRNA degradation, results in hematopoietic stem cell (HSC) expansion and compromises acute … smith and wesson 357 canada

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Sumo ythdf2

The RNA m6A reader YTHDF2 controls NK cell anti-tumor and

WebYTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation Grenov A., Hezroni H., Lasman L., Hanna J. H. & Shulman Z. Cell reports (Cambridge) 2024 Go to publication Web21 Nov 2014 · YTHDF2 is also known to be involved in development of acute myeloid leukemia 12. YTHDC1 (splicing factor YT521-B), another YTH domain-containing protein, …

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WebWe report 17 small-molecule ligands that compete with N6-methyladenosine (m6A) for binding to the m6A-reader domain of YTHDF2 (YT521-B homology domain family 2). We determined their binding mode at high resolution by X-ray crystallography and quantified their affinity by a fluorescence-based binding assay. 6-Cyclopropyluracil and a … WebDianova’s development programme aimed at providing better antibodies for tumor diagnostics redefines antibody performance in immunohistochemistry (IHC).

WebThis gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in … WebIn this study, we report that m 6 A exhibited a marked increase during bacterial infection, and was predominantly enriched in transcripts related to histone modification. Knockout (KO) of YTHDF2, an m 6 A reader, markedly enhanced demethylation of H3K27me3 on the promoters of proinflammatory cytokines (e.g., IL-6 and IL-12B), resulting in increased …

Web15 Feb 2024 · ythdf2的sumo化修饰主要发生在第571位赖氨酸残基上。通过生化、细胞学实验、MeRIP-Seq和RNA-Seq和小分子抑制剂等多种新技术方法，证明了YTHDF2的SUMO … Web10 Aug 2024 · The human YTH domain family (YTHDF) proteins are RNA-binding proteins that recognize N6-methyladenosine (m6A), facilitating various biological processes via …

Web8 Apr 2024 · The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay during cell cycle. Depletion of YTHDF2 in HeLa cells leads to the delay of …

WebThe mRNA N6-methyladenosine (m6A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m6A mRNA reader YTHDF2, which recognizes m6A-modified transcripts to promote m6A-mRNA degradation, results in hematopoietic stem cell (HSC) expansion and compromises acute myeloid leukemia. smith and wesson .357 combat magnumWeb16 Feb 2024 · YTH domain of YTHDF2 was a globular fold with four-stranded β-sheets (β1-β4), four α helices (α1-α4) and flanking regions on two sides. Besides, residues K416 and R527 of the above C-terminal YTH domain greatly participated in targeting RNA backbone and residues W432 and W486 within the hydrophobic pocket. smith and wesson 357 86WebGene "Gene description" Evidence A1CF "APOBEC1 complementation factor" "Evidence at protein level" A4GALT "Alpha 1,4-galactosyltransferase (P blood group)" "Evidence at protein le rite aid sign up for covid shotWeb29 Oct 2024 · YTHDF2 was frequently overexpressed in AML, and the m 6 A modified apoptosis-induced gene TNFRSF2 was targeted by YTHDF2 to decrease its half-life, which … rite aid silverdale washingtonWeb2 Jul 2024 · RNA-binding proteins (RBPs) are aberrantly expressed in cancer, but they remain largely unexplored as drug targets. Using RBP-focused CRISPR-Cas9 screening, Einstein et al. uncover an essential and selective role for YTHDF2 in MYC-driven breast cancer, highlighting the utility of discovering RBPs as safe and effective therapeutic targets. rite aid silverton pharmacyWeb1 Mar 2024 · YTHDF2 was modified by SUMO1 with a size of Mr ~95–100 kDa (the expected normal size of YTHDF2 is 70 kDa), which is YTHDF2 covalently conjugated with one … smith and wesson 357 hunterWebThe loss of YTHDF2 results in the failure to regulate transcript dosage of a cohort of genes during oocyte maturation, with enrichment observed for the YTHDF2-binding consensus and evidence of m6A in these upregulated genes. In summary, the m6A-reader YTHDF2 is an intrinsic determinant of mammalian oocyte competence and early zygotic development.", smith and wesson 357 highway patrol for sale