Labetalol's dual alpha and beta adrenergic antagonism has different physiological effects in short- and long-term situations. In short-term, acute situations, labetalol decreases blood pressure by decreasing systemic vascular resistance with little effect on stroke volume, heart rate and cardiac output. During long-term use, labetalol can reduce heart rate during exercise while maintaining cardiac output by an increase in stroke volume. WebLabetalol is a racemate with alpha and non-selective beta adrenoceptor antagonist activity. 1 The National Institute for Health and Care Excellence (NICE) recommends labetalol as …
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WebApproximately 55% to 60% of a dose appears in the urine as conjugates or unchanged labetalol within the first 24 hours of dosing. Labetalol has been shown to cross the placental barrier in humans. Only negligible amounts of the drug crossed the blood-brain barrier in animal studies. Labetalol is approximately 50% protein bound. WebMar 25, 2024 · Trandate (labetalol) Tablets are indicated in the management of hypertension. Trandate (labetalol) Tablets may be used alone or in combination with other antihypertensive agents, especially thiazide and loop diuretics. DOSAGE AND ADMINISTRATION DOSAGE MUST BE INDIVIDUALIZED. cyclobenzaprine breastfeeding category
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