Irf8 b cell
WebNov 15, 2008 · Exogenous IRF8 rescued B-cell development in IRF8-deficient HSCs, as indicated by the detection of large numbers of B220 + cells (Figure 6B). In contrast, the … WebMar 30, 2024 · IRF8 is a transcription factor that belongs to one of the nine family members of interferon regulatory factors (IRF). IRF8 has a DNA binding domain (DBD; 120 aa) of the helix-turn-helix type and an IRF association domain (IAD) that serves as a recruitment module for other transcription factors.
Irf8 b cell
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WebMar 10, 2011 · Western blot (bottom) shows the IRF8 protein level in total cell lysates. IFN-β transcription in monocytes stimulated with LPS for 2 hours, determined by real-time PCR (top). (B) The mapping of IRF8-binding sites across IFN-β genomic DNA using 5 different pairs of primers (bottom). Primary monocytes were stimulated with LPS for 1 hour before ... WebIRF8 promotes the GC B cell response while inhibiting plasma cell differentiation through the induction of genes that maintain the B cell program and repression of genes that maintain...
WebJun 20, 2024 · IRF8 and EBF1 define pDC and B cell lineage dichotomy. To dissect the heterogeneity of the SP compartment, we used IRF8-eGFP and EBF1-hCD2 reporter mice, which express a 3′ IRES-GFP and an IRES ... WebApr 11, 2024 · CD8 + T cells are crucial for the clearance of viral infections. During the acute phase, proinflammatory conditions increase the amount of circulating phosphatidylserine + (PS) extracellular vesicles (EVs). These EVs interact especially with CD8 + T cells; however, it remains unclear whether they can actively modulate CD8 + T cell responses. In this …
WebApr 4, 2024 · Moreover, IRF8 was detected as a novel fusion partner of IGH in DLBCL, 39,40 and this fusion resulted in higher IRF8 expression levels. 39 In a mouse model of the IGH … WebIRF8 directly controls Zbtb32, a master regulator of the NK cell proliferative burst, and regulates expression of other cell cycle genes that are critical for cellular maturation and …
WebJul 10, 2012 · IRF8 Is an Activation Molecule in CD8 T Cells. IRF8 is the only IRF family member whose expression is confined to immune cells. However, its expression in CD8 T cells has not been extensively studied. Our results ( Fig. S2 A and B) demonstrate the activation-associated expression of IRF8 in OT-I cells. litchfield cityWeb(B) Relative reporter luciferase activity for Naip2 or Naip5 promoters in IRF8-overexpressing cells, presented as fold change with respect to empty vector (EV)-transfected cells. Data were normalized for transfection efficiency by normalizing firefly luciferase activity with renilla luciferase activity. imperial government structureWebAug 5, 2024 · IRF8 is a TF preferentially expressed in hematopoietic cell lineages and critical for normal myeloid cell and B cell development ( Holtschke et al., 1996 ; Lu et al., 2003 ; Tamura et al., 2000 ; Wang et al., 2008 ). IRF8 -deficient mice have compromised immune systems and display a chronic-myelogenous-leukemia-like syndrome ( imperial government 意味WebInfection with ΔfliCΔfljB in Irf8 –/– BMDMs revealed reduced caspase-1 activation and cell death, suggesting that IRF8 is necessary for T3SS-dependent NLRC4 inflammasome … imperial grading systemWebDec 12, 2024 · IRF8 is an important regulator for macrophage, dendritic cells (DC) and B-cell development and function. Like IRF4, IRF8 also requires cooperative binding factors to … imperial governor star warsWebApr 10, 2024 · Genetic classification helps to disclose molecular heterogeneity and therapeutic implications in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA-sequencing, and ... litchfield cleanersWebMay 5, 2024 · Studies using reporter mice have demonstrated that IRF8 is expressed at high levels in all B cell subpopulations except the plasma cells (PCs) ( 17 ). PU.1 is also constitutively expressed in BM-developing B cells and splenic naïve B cells ( 18 ). imperial governor cyoa